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How to Take Anastrozole
Anastrozole is a tablet that is taken by mouth. You can take this medication with or without food. Do not crush, break or chew the tablet. Your health care team will tell you how much medication you should take. If you miss a dose or vomit after taking your dose, do not take an additional dose. Wait to take your next dose at the scheduled time. Do not take two doses at the same time. Do not stop taking anastrozole without talking to your healthcare team.
It is important to make sure you are taking the correct amount of medication every time. Before every dose, check that what you are taking matches what you have been prescribed. If you take too much medication, notify your health care team or go to the emergency room immediately.
The blood levels of this medication can be affected by certain foods and medications, so they should be avoided. Be sure to tell your healthcare provider about all medications and supplements you take. You should not take this medication if you are currently taking tamoxifen or other medications that include estrogen, including hormone replacement therapy, birth control pills, estrogen creams, vaginal ring and vaginal suppositories.
Storage and Handling
Store your medication in the original, labeled container at room temperature and in a dry location (unless otherwise directed by your healthcare provider or pharmacist). This medication should not be stored in a pillbox. Keep containers out of reach of children and pets.
If a caregiver prepares your dose for you, they should consider wearing gloves or pour the pills directly from their container into the cap, a small cup, or directly into your hand. They should avoid touching the pills. They should always wash their hands before and after giving you the medication. Pregnant or nursing women should not prepare the dose for you. Ask your oncology team where to return any unused medication for disposal. Do not flush down the toilet or throw it in the trash.
Where do I get this medication?
Anastrozole is available through your local retail/mail order pharmacy. Your oncology team can work with your prescription drug plan to identify an in-network retail/mail order pharmacy for medication distribution.
This medication may be covered under your prescription drug plan. Patient assistance may be available to qualifying individuals depending upon prescription drug coverage. Co-pay cards, which reduce the patient co-pay responsibility for eligible commercially (non-government sponsored) insured patients, may also be available. Your care team can help you find these resources, if they are available.
Possible Side Effects
There are a number of things you can do to manage the side effects of anastrozole. Talk to your care team about these recommendations. They can help you decide what will work best for you. These are some of the most common or important side effects:
Fatigue is very common during cancer treatment and is an overwhelming feeling of exhaustion that is not usually relieved by rest. While on cancer treatment, and for a period after, you may need to adjust your schedule to manage fatigue. Plan times to rest during the day and conserve energy for more important activities. Exercise can help combat fatigue; a simple daily walk with a friend can help. Talk to your healthcare team for helpful tips on dealing with this side effect.
There are a few things you can do to help with hot flashes. Several medications have been shown to help with symptoms, including clonidine (a blood pressure medication), low doses of certain antidepressants (such as venlafaxine and fluoxetine), and gabapentin. Talk to your healthcare team about these prescription products to determine if they are right for you.
Non-medical recommendations include:
- Keep well-hydrated with eight glasses of water daily.
- Drink ice water or apply an ice pack at the onset of a hot flash.
- Wear cotton or lightweight, breathable fabrics and dress in layers so you can adjust as needed.
- Exercise on a regular basis.
- Try practicing meditation or relaxation exercises to manage stress, which can be a trigger.
- Avoid triggers such as warm rooms, spicy foods, caffeinated beverages, and alcohol.
Muscle or Joint Pain/Aches and Headache
Aromatase inhibitor medications can cause joint or muscle aches and pains, which can interfere with the quality of life. Be sure to talk to your oncology care team if you develop this side effect. This pain is caused mainly by swelling in the joints, which is best treated by a non-steroidal anti-inflammatory (NSAID), such as ibuprofen (Advil/Motrin), naproxen (Aleve), and celecoxib (Celebrex). Be sure to discuss which pain relievers you can safely take with your oncology team, as these are not without their own side effects. Studies have shown that acupuncture and gentle stretching and exercise may also help reduce this pain.
Vaginal dryness and related painful intercourse is one of the more common side effects of cancer therapy in women. Vaginal lubricants and moisturizers (longer-lasting forms of moisturizers) can help with these concerns. Talk to your healthcare team for more suggestions in managing this side effect.
Nausea and/or Vomiting
Talk to your oncology care team so they can prescribe medications to help you manage nausea and vomiting. In addition, dietary changes may help. Avoid things that may worsen the symptoms, such as heavy or greasy/fatty, spicy or acidic foods (lemons, tomatoes, oranges). Try saltines, or ginger ale to lessen symptoms.
Call your oncology care team if you are unable to keep fluids down for more than 12 hours or if you feel lightheaded or dizzy at any time.
Your oncology care team can recommend medications to relieve diarrhea. Also, try eating low-fiber, bland foods, such as white rice and boiled or baked chicken. Avoid raw fruits, vegetables, whole-grain breads, cereals, and seeds. Soluble fiber is found in some foods and absorbs fluid, which can help relieve diarrhea. Foods high in soluble fiber include applesauce, bananas (ripe), canned fruit, orange sections, boiled potatoes, white rice, products made with white flour, oatmeal, cream of rice, cream of wheat, and farina. Drink 8-10 glasses of non-alcoholic, un-caffeinated fluid a day to prevent dehydration.
Weakening of the Bones (Osteoporosis)
You may be advised to get plenty of calcium and vitamin D to reduce your risk of osteoporosis. It is best to get calcium in a balanced diet, including 4-8 servings of calcium-rich foods a day. Examples of calcium-rich foods are low-fat milk, yogurt, cheese, green leafy vegetables, nuts, seeds, beans, legumes, and calcium fortified foods and juices. Vitamin D is not present in many foods, so it is harder to get in your diet. Our bodies make vitamin D when the sun hits our skin, but sun avoidance and sunblock prevent many from getting the necessary amounts to support bone health. Your care team may recommend supplements of calcium and vitamin D and will tell you how much to take. Weight-bearing exercise and strength exercises can also help protect your bone health.
Your provider will check your bone health before starting therapy. This is done with a bone density scan (DEXA scan). Women with no weakening of bones prior to aromatase inhibitor therapy will have a follow-up scan around one year after starting therapy, and then every one to two years. If the scan shows that you already have some bone weakening, your doctor may order a type of medication called a bisphosphonate. These therapies have been shown to protect the bones from bone loss in women taking aromatase inhibitors. If the bone density remains stable, scans can then be done every two years.
Some women report mood swings and depression while on hormone therapy. It can be helpful to talk about concerns and feelings with a partner or close friend. If you find that feelings of sadness are interfering with life, talk with your team about finding a counselor experienced in working with cancer patients.
Less common, but important side effects can include:
- Increased Blood Cholesterol: Anastrozole can cause an increase in your cholesterol levels. Your healthcare team will monitor your cholesterol levels throughout your treatment.
- Heart Problems: This medication may increase symptoms of decreased blood flow to the heart in women who have a history of a blockage in their arteries. If you experience new or worsening chest pain or shortness of breath go to the emergency room immediately.
- Liver Toxicity: This medication can cause liver toxicity, which your doctor will monitor for using blood tests called liver function tests. Notify your healthcare provider if you notice yellowing of the skin or eyes, your urine appears dark or brown or pain in your abdomen, as these can be signs of liver toxicity.
Exposure of an unborn child to this medication could cause birth defects, so you should not become pregnant or father a child while on this medication. Effective birth control is necessary during treatment and for at least 3 weeks after treatment. Even if your menstrual cycle stops or you believe you are not producing sperm, you could still be fertile and conceive. Do not breastfeed while taking this medication and for two weeks after treatment has ended.
Arimidex® Pricing Information
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What is Arimidex®
ARIMIDEX® 1 mg is a prescription hormonal treatment that helps fight breast cancer by lowering the amount of estrogen in the body. ARIMIDEX® is a selective, non-steroidal aromatase inhibitor, which significantly lowers serum estradiol (estrogen) concentrations, without interfering with the formation of adrenal corticosteroids or aldosterone.
This program is not insurance or a discount card. Patients must have a valid prescription. Taxes may apply. Orders processed without the use of insurance may not be submitted for reimbursement to any state or federally funded programs such as Medicare or Medicaid, and are not eligible to be applied to Medicare Part D true out of pocket (TrOOP). The manufacturer, or its affiliates, reserve the right to rescind, revoke, or amend this program at any time without notice. .
Patients should always ask their doctors for medical advice about adverse events.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/MedWatch or call 1-800-FDA-1088.
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Infratil Airports Europe: December 2006 Traffic Statistics
... , reduced capacity on a number of Ryanair routes during the winter has had an adverse effect on passenger throughput ... at the airport, with 2,481 tonnes handled. The 10.5% year on ... the 2006 volume is more than double the December 2005 volume of 1 ... , announced during the month that they will be based on-site at ... a slight decrease onthe prior year total. Load factors overthe festive period ... 2006. The total of 651,232 is down 4% on 2005, however ...
... Infratil Infrastructure Bonds are listed onthe NZDX. Most trade regularly, but ... .a. overthe one year Bank Rate * as at that day. The Bond ... of 2.5% p.a. overthe then five year Bank Rate ... one year return of 1.5% p.a. overthe one year Bank Rate * as at that day. The special ... ,200 The coupon rate is reset every 15 Novemberat 1.5% overthe then ... Bonds are listed onthe NZX and most trade on a regular basis ... covers the history of the PiiBs and factors investors should consider when buying ...
2019 Annual Report Highlights
... price risk on behalf of consumers. The only complaints voiced overthe period came ... Zealand retail electricity sales 1,823GWh 1,784GWh 1,895GWh New Zealand generation ... the US using experienced local management, and the capital and investment discipline of the ... ’s overarching goals are to buy or create development options, to ... invested and returned in short order. As at 31 March 2019 ... 3.8% per annum. On a daily basis that’s approximately 90 ...
... Interim 6.250c 0.794c 1.750c 15 Dec 2020 05 ... onthe New Zealand register)https://investorcentre.linkmarketservices.com.au (for holders onthe ... the shares issued under the DRP will be the weighted average price recorded onthe NZX for Infratil shares overthe 5 trading days from the relevant ... by Infratil onthe market. Any new shares issued under the DRP will ...
2016 Annual Report Highlights
... invested $819 million building and buyingthe existing 385 MW. Trustpower’s ... more passengers usedthe Airport than the prior year; about three times the usual ... $252.9m NZ$208.6m 1. The values are point in time ... making good progress on its expansion plans and overthe six months to 31 December 2015 it completed the construction ... contribution to Infratil overthe year. Infratil acknowledges the excellent contribution overthe last seven ...
CEO and Board Chair Report
2019 Annual Report Highlights
... underway over a longer period. Overthe last five years Infratil has realised $1 ... -like” investments. Buying a low risk income stream in the form of ... the Commerce Commission. Whether the Commission makes good use of the powers was not the ... performance. Reporting onthe target, performance relative to the target, and on managementNothing has ... , the rate of return, and the performance fee components. The fee reflects performance overthe ...
2019 Annual Report Highlights
... (the lines activities) and use of the proceeds to buy more generation; and the expansion ... only grew US$1,000 to US$18,705 overthe 25 years to 31 December 2018 (and the US$ depreciated against the NZ$ over that period).The graph also shows Infratil's main investments overthe ... usedthe Airport. Overthe subsequent twenty years $648 million has been invested by the ... values reflect the price of their shares onthe NZX onthe relevant dates.The other ...
2017 Annual Report Highlights
... technology changes. Overthe last four years Infratil has raised over $1,500 million from divestment and allocated $940 million to the ... the creation of Tilt Renewables. Overthe last four years Infratil has raised over $1,500 million from divestments and allocated $940 million to the ... motor fuel is not rising. Onthe other hand, Canberra Data Centres ... is listed onthe NZX. Tilt Renewables is listed onthe NZX and ASX ...
Infratil Releases Newsletter on the Electricity Crisis
... total inflows overthe first seven months of the year the driest in the last ... Infratil put it in the newsletter 'The score sheet onthe market is struggling for a restricted pass mark'. Infratil considers the ... price up the surplus to improve what they can earn onthe spot ... features of the New Zealand market means all the focus on how well it works needs to be placed on ... through of these to end use customers. some minor improvements in ...
Announcement of Results for the Year Ended 31 March 1999
... .9 million overthe $9.9 million earned for the same period last ... 162.8% increase overthe $10.1 million earned for the same period last ... the Company. The acquisition of the WIAL stake was made in two steps. On ... payment for the 39.6% stake in WIAL acquired through buying out ... on 22 December 1998. The Infrastructure Bonds and Infratil Warrants commenced trading onthe ... appropriate to disclose a valuation using prices at which small minority ...
TrustPower Results for the Year Ended 31 March 2008
... than expected wind speeds overthe second half of the financial year and ... andcommissioned overthe next three months. If all goes to plan the project ... to buy-back up to 5 million of its shares overthe next sixmonths. Given the current volatility in financial markets the Board considers that the Company should havethe flexibility to buy back ... .On1 May 2008 Transpower, as the independent system operator, advised that despite the ...
Infratil and Guardians of NZ Superannuation Agree the Purchase of Shell NZ Downstream Assets
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TrustPower Unaudited Results for the Six Months Ended 30 September 2010
... includes the impact of fair value movements on financial instruments and the one ... down 1 per cent onthe prior period. Total electricity volume sold by the ... March 2010. The Company was successful in countering some of the impact of ... of the country. Time of use sales were up 5 per cent on prior period as the ... subordinated bonds the Company currently has just over NZD equivalent of 1.1 billion ... million. Stage 1 of the 36MW Mahinerangi Wind Farm remains on schedule for ...
Z Energy results for the year end 31 March 2013
... .0 million for the previous corresponding period.(1) On a current cost basis ... fluctuations in the value and volume of stock held overthe period, due ... Z overthe last 12 months to deliver substantial savings for the company ... , Z is positioning itself to use larger and more cost-effective ... . “buy low, sell high”), but to seek to generate sustainable margin on ... results over time. The Z Energy Group provides information on its earnings based on ... . “buy low, sell high”), but to seek to generate sustainable margin on ...
Infratil Results for the year ended 31 March 2013
... $188 million in the prior year. Capital expenditure(1) was $414 million ... the prior year. The dividend will be paid on 14 June to shareholders onthe register as at 31 May. The ... able to invest in expansion. Overthe last year each of our ... made the sale of the airports unpredictable and difficult. Onthe other hand, the latter ... buy-backs will continue to be an option, especially if the shares ... %, down from 42% in the prior year. Overthe year Infratil issued 3 ...
Infratil successfully concludes the Equity Raising
NZX / ASX Announcements
... .35 per share (8.7%) overthe Application Price of NZ$4 ... $0.05 per share (1.1%) to the theoretical ex-rights price of ... by the Registrar at the prevailing exchange rate for buying Australian dollars using New Zealand dollars at the ... expected to occur on Tuesday, 18 June 2019.The Retail Premium will ... , or the solicitation of an offer to buy, any securities in the United ...
Interim results for the period ended 30 September 2019
NZX / ASX Announcements
... three new renewable generation projects overthe period amounting to 755MW of ... is underway on 177 units at The Verge village adjacent to the Burleigh ... which could involve $1,000 million of investment overthe next decade expanding capacity and improving resilience.While the six ... million for the year ending 31 March 2020.Overthe 6 months the Infratil ... . In addition, shareholders had the opportunity to buy one share at $4 ...
Trustpower pleased to announce wireless broadband and mobile services on the way
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Port of Tauranga Results for the Year to 30 June 2006
... down onthe previous year by 161,600 tonnes (26.3%). "Onthe more ... amounted to 1.130 million tonnes, which represents an increase over last ... ,000 tonnes)." Onthe container side of the business, total for the year was ... and the completion of deepening of berths used by Genesis for the importation ... shareholders for the year to 20.0 cents, unchanged over 2005. "The Company ... in the forestry sector. The weakening in the NZ currency, despite its effect on ...
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